A spiking model of basal ganglia dynamics in stopping behavior supported by arkypallidal neurons

The common view that stopping action plans by the basal ganglia is achieved mainly subthalamic nucleus alone due to its direct excitatory projection onto output nuclei of has been challenged recent findings. proposed “pause-then-cancel” model suggests provides a rapid stimulus-unspecific “pause” signal, followed stop-cue-specific “cancel” signal from striatum-projecting arkypallidal neurons. To determine more precisely relative contribution different in stopping, we simulated stop-signal task with spiking neuron ganglia, considering recently discovered connections neurons, and cortex-projecting GPe For prototypical obtained parameters fitting their neuronal responses published experimental data. Our replicates findings tasks at behavioral levels. We provide evidence for existence stop-related cortical input neurons such stop nucleus, complement each other achieve functional behavior. Particularly, may within caused STN diminishing go-related processes. Furthermore, predict effects lesions on performance propose participate inhibiting striatal indirect rather than pathway.